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KMID : 1140120110160010086
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Cancer Prevention Research
2011 Volume.16 No. 1 p.86 ~ p.92
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Protective Effect of Bitter Melon (Momordica charantia) against Oxidative Stress
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Sin Seung-Mi
Mok So-Youn
Lee Sang-Hyun
Cho Kye-man
Cho Eun-Ju
Kim Hyun-Young
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Abstract
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This study was focused on the evaluation of antioxidative effect of bitter melon (Momordica charantia L.). Bitter melon was extracted with methanol and then fractionated into 4 fractions (hexane, methylene chloride, ethyl acetate, and butanol fractions). The protective effect of bitter melon against oxidative stress was investigated under in vitro and cellular system. The extract and fractions from bitter melon exerted strong scavenging activity of 1,1-diphenyl-2-picrylhydrazyl and hydroxyl radical. Protective effects of bitter melon from nitric oxide (NO), and peroxynitrite under cellular oxidative stress model using LLC-PK1
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KEYWORD
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Bitter melon (Momordica charantia L.), DPPH, ㆍOH, Oxidative stress, LLC-PK1, 3-Morpholinosydnonimine, Sodium nitroprusside
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